183 -  Krzyscik, M., Zakrzewska, M., Sørensen, V., Sokolowska-Wedzina, A., Lobocki, M., Swiderska, K., Krowarsch, D., Wiedlocha, A. & Otlewski, J. (2017) Cytotoxic Conjugates of Fibroblast Growth Factor 2 with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors. ACS Omega – in press.

182 -   Opalinski, L., Szczepara, M., Sokolowska-Wedzina, A., Zakrzewska, M. & Otlewski, J. (2017) The Autoinhibitory Function of D1 Domain of FGFR1 Goes Beyond the Inhibition of Ligand Binding. Int. J. Mol. Sci – in press.

181 -   Lobocki, M.,Zakrzewska, M.,  Szlachcic, A., Krzyscik, M., Sokolowska-Wedzina, A. & Otlewski, J. (2017) High-yield Site-specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues. Bioconjugate Chem. – in press.

180 -  Swiderska, K.W., Szlachicic, A., Czyrek, A., Zakrzewska, M. & Otlewski, J. (2017) Site-specific Conjugation of Fibroblast Growth Factor 2 (FGF2) Based on Incorporation of Alkyne-reactive Unnatural Amino Acid. Bioorg. Med. Chem. doi: 10.1016/j.bmc.2017.05.003.

179 - Sokolowska-Wedzina, A., Chodaczek, G., Chudzian, J., Borek, A., Zakrzewska, M. & Otlewski, J. (2017)  Generation of High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer Cells. Mol. Cancer Res. doi: 10.1158/1541-7786.MCR-16-0136.

178 - Serwotka-Suszczak, A.M., Sochaj-Gregorczyk, A.M., Pieczykolan, J., Krowarsch, D., Jelen,F. & Otlewski, J. (2017) A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-positive Cancer Cells. Int. J. Mol. Sci. 18(2), 401; doi:10.3390/ijms18020401.

177 - Sochaj-Gregorczyk, A. Serwotka, A. & Otlewski, J. (2016) Novel Affibody-auristatin E Conjugate with a Potent and Selective Activity against HER2-positive Cell Lines. J. Immunotherapy 39, 223-232.

176 -  Jurek,P. M.,Zablocki,K.,Wasko,U.,Mazurek, M.P.,Otlewski,J. & Jelen, F. (2017) Anti-FGFR1 Aptamer-tagged Superparamagnetic Conjugates for Anti-cancer Hyperthermia. Int. J. Nanomedicine 12, 2941-2950.

175 - Szlachcic, A., Zakrzewska, M. Łobocki, M., Jakimowicz, P. Otlewski, J. (2016) Design and Characteristics of Cytotoxic Fibroblast Growth Factor 1 (FGF1) Conjugate for the FGF Receptor-targeted Cancer Therapy. Drug Design, Development and Therapy 10, 2547-2560.

174 - Bober, J., Olsnes, S., Kostas, M., Bogacz, M., Zakrzewska, M. & Otlewski, J. (2016) Identification of New FGF1 Binding Partners – Implications for its Intracellular Function. IUBMB Life. 68, 242-251.

173 - Wezner-Ptasinska, M. & Otlewski, J. (2015) Selection of specific interactors from phage display library based on sea lamprey variable lymphocyte receptor sequences. Biochim. Biophys. Acta - Proteins Proteomics. 1854(12), 1833-41. [PubMed]

172 - Sochaj, A.M., Swiderska, K.W. & Otlewski, J. (2015) Current methods for the synthesis of homogeneous antibody-drug conjugates. Biotechnol. Adv. 33(6 Pt 1), 775-84. [PubMed]

171 - Petters, E., Sokolowska-Wedzina, A. & Otlewski, J. (2015) Selection and characterization of single chain antibody fragments specific for Hsp90 as a potential cancer targeting molecule. Int. J. Mol. Sci. 16(8), 19920-19935. [PubMed]

170 - Pala, K., Jakimowicz, P., Cyranka-Czaja, A. & Otlewski, J. (2015) The synthesis of multifunctional nanoparticles conjugated with anti-Her2 affibody and monomethylauristatin E. Mater. Res. Express. 2, 045403. [link]

169 - Buchtova, M., Vesela, I., Zakrzewska, M., Chaloupkova, R., Cela, P., Zajickova, R., Trantirek, L., Martin, J., Balek, L.,Kostas, M., Otlewski, J.,Damborsky, J., Kozubik,A., Wiedlocha, A. & Krejci, P. (2015) Instability Restricts Signaling of Multiple Fibroblast Growth Factors . Cellular and Molecular Life Sciences. 72(12), 2445-59. [PubMed]

168 - Wawiórka, L., Krokowski, D., Gordiyenko, Y., Krowarsch, D., Robinson, C.V., Adam, I., Grankowski, N. & Tchórzewski, M. (2015) In vivo formation of Plasmodium falciparum ribosomal stalk - a unique mode of assembly without stable heterodimeric intermediates. Biochim Biophys Acta. 1850, 150-158. [PubMed]

167 - Nadratowska-Wesolowska, B., Haugsten, E.M., Zakrzewska, M., Jakimowicz, P., Zhen, Y., Pajdzik, D., Wesche, J. & Wiedlocha, A. (2014) RSK2 regulates endocytosis of FGF receptor 1 by phosphorylation on serine 789. Oncogene. 33(40), 4823-36. [PubMed]

166 - Sokolowska-Wedzina, A., Borek, A., Chudzian, J., Jakimowicz, P., Zakrzewska, M. & Otlewski, J. (2014) Efficient Production and Purification of Extracellular Domain of Human FGFR-Fc Fusion Proteins from Chinese Hamster Ovary Cells. Protein Expression Purif. 99C, 50-57. [PubMed]

165 - Pala, K., Serwotka, A., Jeleń,F., Jakimowicz, P.,Otlewski, J. (2014) Tumor-specific Hyperthermia with Aptamer-tagged Superparamagnetic Nanoparticles. Int. J. Nanomedicine 9, 67-76. [PubMed]

164 - Sletten, T., Kostas, M., Bober, J., Sorensen, V., Yadollahi, M., Olsnes, S., Tomala, J., Otlewski, J., Zakrzewska, M. & Wiedlocha, A. (2014) Nucleolin Regulates Phosphorylation and Nuclear Export of Fibroblast Growth Factor 1 (FGF1). PLoS One 9(3), e90687 doi: 10.1371/journal.pone.0090687. eCollection 2014. [PubMed]

163 - Kobielak, A., Zakrzewska, M., Kostaś,, M., Jakimowicz, P., Otlewski, J. & Krowarsch, D. (2014) Protease Resistant Variants of FGF1 with Prolonged Biological Activity. Protein Peptide Lett. 21, 434-443. [PubMed]

162 - Sosicka, P., Jakimowicz, P., Olczak, T., Olczak, M. (2014) Short N-terminal region of UDP-galactose transporter (SLC35A2) is crucial for galactosylation of N-glycans. Biochem Biophys Res Commun. 454(4), 486-492. [PubMed]

161 - Petters, E., Krowarsch, D. & Otlewski, J. (2013) Design, Expression and Characterization of a Highly Stable Tetratricopeptide-based Protein Scaffold for Phage Display Application. Acta Biochim. Polon. 60, 585-590. [PubMed]

160 - Olczak, M., Maszczak-Seneczko, D., Sosicka, P., Jakimowicz, P., Olczak, T. (2013) UDP-Gal/UDP-GlcNAc chimeric transporter complements mutation defect in mammalian cells deficient in UDP-Gal transporter. Biochem Biophys Res Commun. 434(3), 473-478. [PubMed]

159 - Maszczak-Seneczko, D., Sosicka, P., Olczak, T., Jakimowicz, P., Majkowski, M., Olczak M. (2013) UDP-N-acetylglucosamine transporter (SLC35A3) regulates biosynthesis of highly branched N-glycans and keratan sulfate. J Biol Chem. 288(30), 21850-21860. [PubMed]

158 - Radom, F., Jurek, P.M., Mazurek, M.P., Otlewski, J. & Jelen, F. (2013) Aptamers: Molecules of Great Potential, Biotechnology Advances31, 1260-1274. [PubMed]

157 - Kochanczyk, T., Jakimowicz, P., Krezel, A. (2013) Femtomolar Zn(II) affinity of minimal zinc hook peptides - a promising small tag for protein engineering. Chem Commun (Camb).  49(13), 1312-1314. [PubMed]

156 - Zakrzewska, M.; Haugsten, E.M.; Nadratowska-Wesolowska, B.; Oppelt, A.; Hausott, B.; Jin, Y.; Otlewski, J.; Wesche, J.; Wiedlocha, A. (2013) ERK-Mediated Phosphorylation of Fibroblast Growth Factor Receptor 1 on Ser 777 Inhibits Signaling. Science Signaling 6 (262), ra11. [DOI: 10.1126/scisignal.2003087]. [PubMed]

155 - Otlewski, J. (2012) "DNA, Genes and Molecular Medicine" Przegląd Uniwersytecki, pismo informacyjne Uniwersytetu Wrocławskiego, 10, 10-12. [link]

154 - Cyranka-Czaja, A. & Otlewski, J. (2012) A Novel, Stable, Helical Scaffold as an Alternative Binder - Construction of Phage Display Libraries. Acta Biochim. Polon. 59, 383-390. [PubMed]

153 - Sikorska, M., Krezel, A. & Otlewski, J. (2012) Femtomolar Zn2+ affinity to LIM domain of Elfin protein uncovers crucial contribution of protein-protein interactions to protein stability. J. Inorganic Biochem. 115, 28-35. [PubMed]

152 - Cyranka-Czaja, A., Wulhfard, S., Neri, D., & Otlewski, J. (2012) Selection and characterization of human antibody fragments specific for Psoriasin - a cancer associated protein. Biochem. Biophys. Res. Commun. 419, 250-255 [PubMed]

151 - Szlachcic, A., Pala, K., Zakrzewska, M., Jakimowicz, P., Wiedlocha, A., Otlewski, J. (2012) FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation. Int J Nanomedicine. 7, 5915-5927. [PubMed]

150 - Borowik, T., Przybylo, M., Pala, K., Otlewski, J., Langner, M. (2011) Quantitative Measurements of Au and Fe in Ferromagnetic Nanoparticles with Laser Induced Breakdown Spectroscopy Using a Polymer-based Gel Matrix. Spectrochimica Acta Part B: Atomic Spectroscopy 66, 726-732. [link]

149 - Zakrzewska, M., Szlachcic, A., Otlewski, J. (2011) Tailoring Small Proteins Towards Biomedical Applications. Curr Pharm Biotechnol. 12, 1792-1798. [PubMed]

148 - Maszczak-Seneczko, D., Olczak, T., Jakimowicz, P., Olczak, M. (2011) Overexpression of UDP-GlcNAc transporter partially corrects galactosylation defect caused by UDP-Gal transporter mutation. FEBS Lett. 585(19), 3090-3094.[PubMed]

147 - Śmietana, K., Mateja, A., Krężel, A., Otlewski, J. (2011) PDZ domain from Dishevelled - a specificity study. Acta Biochim Pol. 58, 243-249. [PubMed]

146 - Wezner-Ptasińska, M., Krowarsch, D., Otlewski, J. (2011) Design and characteristics of a stable protein scaffold for specific binding based on variable lymphocyte receptor sequences. Biochim Biophys Acta. 1814, 1140-1145. [PubMed]

145 - Szlachcic, A., Zakrzewska, M., Otlewski, J. (2011) Longer action means better drug: tuning up protein therapeutics. Biotechnol Adv. 29, 436-441. [PubMed]

 

 
 
 
 
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