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Informacja o projekcie

 

SPATIAL ORGANIZATION OF FGF RECEPTOR 1 BY MULTIMERIC LIGAND ASSEMBLIES

 

Fibroblast growth factor receptor 1 (FGFR1) is a receptor tyrosine kinases that together with extracellular fibroblast growth factors (FGFs) transduce signals through the plasma membrane. The FGFRs-FGFs signaling cascades regulate a variety of biological processes, including angiogenesis, embryogenesis, tissue repair and metabolism. Importantly, the aberrant FGFRs-FGFs signaling axis leads to the severe developmental disorders and cancer.

 

AIM OF THE PROJECT:

The goal of this project is to establish how plasma membrane organization of FGFR1 affects receptor function. By employing different FGFR1 ligands and their configurations in the multimeric ligand assemblies (MLAs), the spatial requirements for FGFR1 activity and internalization will be assessed (Fig. 1). We predict that MLAs will constitute a tool for adjusting FGFR1 activity and thus selective modulation of cell response. FGFR1 dimerization induces FGFR1 internalization. With MLAs we intend to cluster FGFR1 into higher order assemblies to boost receptor endocytosis, which we intend to utilize to enhance selective delivery of cytotoxic drugs into FGFR1 overproducing cancer cells.

 

fig1

Fig. 1. Regulation of FGFR1 oligmeric state and function by natural ligand – FGF1 and multimeric ligand assemblies MLAs designed and prepared in the frame of this project.

 

RESEARCH TEAM:

Łukasz Opaliński (PhD) – project leader

Natalia Porębska (Msc) – PhD student

Marta Latko (Msc) – PhD student

Marika Kucińska (Bsc) – student

Agata Knapik – volunteer

 

Project is realized in a collaboration with the group of Prof. Marta Miączyńska from International Institute of Molecular and Cell Biology, Warsaw, Poland

 

The „Spatial organization of FGF receptor 1 by multimeric ligand assemblies (First TEAM/2017-4/38)” project is carried out within the First TEAM programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund.

Budget of the project: 1 999 572 PLN

Project duration: 07.2018 – 06.2021

 

CONTACT:

Łukasz Opaliński (PhD)

lukasz.opalinski@uwr.edu.pl

Tel. +48 71375 2631

 

 

 

 

 

 

 

 
 
 
 
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